Tricyclic antidepressants have been linked to an increased risk of heart disease in a new study of nearly 15,000 people in Scotland. Researchers from University College London found that tricyclic antidepressants, an older class of antidepressant, were associated with a 35% increased risk of CVD (cardiovascular disease), but that there was no increased risk with newer antidepressants such as the selective serotonin reuptake inhibitors (SSRIs). In the study, 14,784 men and women without a known history of CVD were studied using data from the Scottish Health Survey. The researchers combined data from separate surveys in 1995, 1998, and 2003 in adults over 35 and linked them with records on hospital admissions and deaths, with follow-up until 2007. Anyone with a history of clinically confirmed CVD was excluded. Over an average of eight years there were 1,434 cardiovascular events, and just over 26% were fatal. Of the study participants, 2.2% reported taking tricyclic antidepressants, 2% SSRIs, and 0.7% other antidepressants. After adjusting for various factors, the researchers found there was a 35% increased risk of CVD associated with tricyclic antidepressants. The use of SSRIs was not associated with any increased risk of CVD, nor did the researchers find any significant associations between antidepressant use and deaths from any cause. People using the medication should not stop using it, researchers say.
- Some Antidepressants May Cause Heart Disease (healthmad.com)
- Tricyclic anti-depressants linked to increased risk of heart disease (physorg.com)